Prognostic Utility of Initial Lactate in Patients With Acute Drug Overdose: A Validation Cohort.

ABSTRACT: STUDY OBJECTIVE:Previous studies have suggested that the initial emergency department (ED) lactate concentration may be an important prognostic indicator for inhospital mortality from acute drug poisoning. We conduct this cohort study to formally validate the prognostic utility of the initial lactate concentration in a larger, distinct patient population with acute drug overdose. METHODS:This observational, prospective, cohort study was conducted during 5 years at 2 urban teaching hospitals. Consecutive adult ED patients with acute drug overdose had serum lactate levels tested as part of clinical care. The primary outcome was inpatient fatality. Receiver operating characteristics were plotted to determine optimal cut points, test characteristics, area under the curve, odds ratios, and 95%

SUBMITTER: Cheung R 

PROVIDER: S-EPMC6014898 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature