YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6.

ABSTRACT:

Rationale

Microvascular inflammation and endothelial dysfunction secondary to unchecked activation of endothelium play a critical role in the pathophysiology of sepsis and organ failure. The intrinsic signaling mechanisms responsible for dampening excessive activation of endothelial cells are not completely understood.

Objective

To determine the central role of YAP (Yes-associated protein), the major transcriptional coactivator of the Hippo pathway, in modulating the strength and magnitude of endothelial activation and vascular inflammation.

Methods and results

Endothelial-specific YAP knockout mice showed increased basal expression of E-selectin and ICAM (intercellular adhesion molecule)-1 in endothelial cells, a greater number of adherent neutrophils in postcapillar

SUBMITTER: Lv Y 

PROVIDER: S-EPMC6014930 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature