[Expression of PEPT2 mRNA in lung tissue of rats with pulmonary fibrosis].

ABSTRACT:

Background and objective

Pulmonary fibrosis is a common pathological phenomenon in lung cancer patients after chemotherapy or radiotherapy. It is also a key hindrance to the transport of drugs to lung tissue. Peptide transporters have become a target of the rational design of peptides and peptide drugs. The aim of this study is to investigates the expression of peptide transporter 2 (PEPT2) mRNA in the lungs of rats with bleomycin (BLM)-induced pulmonary fibrosis.

Methods

Fifty healthy adult Sprague-Dawley rats were randomly divided into five groups. One group was untreated (control), the second group was injected with normal saline solution (NS), and the three remaining groups were treated with a single dose of bleomycin to induce pulmonary fibrosis (BLM). Rats from the NS

SUBMITTER: Li L 

PROVIDER: S-EPMC6015171 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature