Inflammation, Autophagy, and Apoptosis After Myocardial Infarction.

ABSTRACT: There is evidence for inflammation, autophagy, and apoptosis in the ischemic heart. Autophagy is a physiologic process for tissue survival. Apoptosis, on the other hand, is a mechanism that serves to clear the debris in the setting of tissue injury. The balance between autophagy and apoptosis may be important in cell survival and cardiac function. We examined the interplay of inflammation and myocyte autophagy and apoptosis during the ischemic process. We subjected mice to total left coronary artery ligation and studied these animals for up to 4 weeks. The inflammatory (tumor necrosis factor [TNF]-α, monocyte chemoattractant protein-1, interleukin-6, and interleukin-1β) and autophagic signals (light chain-3 and beclin-1) were strongest during the first week and then began to decline. Howev

SUBMITTER: Wang X 

PROVIDER: S-EPMC6015297 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature