Novel Phospholipid Signature of Depressive Symptoms in Patients With Coronary Artery Disease.

ABSTRACT: Depression in patients with coronary artery disease (CAD) is associated with increased cardiovascular morbidity. Given the proinflammatory actions of phospholipids, aberrant phospholipid metabolism may be an etiological mechanism linking CAD and depression. Our primary objective was to identify a phospholipid biomarker panel that characterizes CAD patients with significant depressive symptoms from those without. We performed a targeted lipidomic analysis on CAD patients with significant depressive symptoms (n=37, Center for Epidemiologic Studies Depression score ≥16) and those without (n=49). Phospholipid species were selected using partial least-square discriminant analysis, and the ability of the resulting model to discriminate between groups was evaluated using receiver operator charact

SUBMITTER: Chan P 

PROVIDER: S-EPMC6015327 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature