Single-Beat Estimation of Right Ventricular Contractility and Its Coupling to Pulmonary Arterial Load in Patients With Pulmonary Hypertension.

ABSTRACT: An accurate assessment of intrinsic right ventricular (RV) contractility and its relation to pulmonary arterial load is essential for the management of pulmonary hypertension. The pressure-volume relationship with load manipulation is the gold standard assessment used for this purpose, but its clinical application has been hindered by the lack of a single-beat method that is valid for the human RV. In the present study, we sought to validate a novel single-beat method to estimate the preload recruitable stroke work (PRSW) and its derivative for ventriculoarterial coupling in the human RV. A novel single-beat slope of the PRSW relationship (Msw) was derived by calculating the mean ejection pressure when the end-systolic volume was equal to volume-axis intercept of the PRSW relationship. In

SUBMITTER: Inuzuka R 

PROVIDER: S-EPMC6015338 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature