Relationship Between Glycated Hemoglobin and Stroke Risk: A Systematic Review and Meta-Analysis.

ABSTRACT: BACKGROUND:Diabetes mellitus is a major risk factor for ischemic stroke. Rising hemoglobin A1c (HbA1c) levels are associated with microvascular diabetes mellitus complication development; however, this relationship has not been established for stroke risk, a macrovascular complication. METHODS AND RESULTS:We conducted a systematic review and meta-analysis of observational cohort and nested case-control cohort studies assessing the association between rising HbA1c levels and stroke risk in adults (≥18 years old) with and without type 1 or type 2 diabetes mellitus. Random-effects model meta-analyses were used to calculate pooled adjusted hazard ratios (HRs) and their precision. The systematic review yielded 36 articles, of which 29 articles (comprising n=532 779 participants) were included i

SUBMITTER: Mitsios JP 

PROVIDER: S-EPMC6015363 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature