Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus.

ABSTRACT:

Background

Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus.

Methods and results

We used both in vitro and ex vivo approaches to test the effects of pharmacological inhibition of Rac1 during hyperglycemic condition. We evaluated the effect of NSC23766, a pharmacological inhibitor of Rac1, on vascular function in diabetic mice and platelet aggregation in diabetic subjects. We demonstrated that the administration of NSC23766 protects from hyperglycemia-induced endothelial dysfunction, restoring NO levels, and reduces oxidative

SUBMITTER: Schiattarella GG 

PROVIDER: S-EPMC6015399 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature