Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics.

ABSTRACT:

Background

Tumor metastasis is the primary cause of mortality in cancer patients. Migratory breast cancer cells in lymphatic and blood vessels seek new sites and form metastatic colonies in the lung and bone, and then these cancer cells often wreak considerable havoc. With advances in nanotechnology, nanomaterials and nanotechnologies are widely applied in tumor therapy. In this paper, small size fullerenol nanoparticles, which are separated by isoelectric focusing electrophoresis (IFE) for discrepancy of isoelectric point (pI), are used in the study of tumor metastasis.

Results

In this study, the commendable inhibition of tumor metastasis was uncovered by intravenous injection of purified fullerenol fraction with special surface charge and functional groups, which was separ

SUBMITTER: Qin Y 

PROVIDER: S-EPMC6015447 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature