Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates.

ABSTRACT:

Background

Alzheimer's disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains incomplete, which hampers the development of effective treatments. In fact, currently, there are no effective pharmacological treatments for AD. Integrative strategies such as transcription regulatory network and master regulator analyses exemplify promising new approaches to study complex diseases and may help in the identification of potential pharmacological targets.

Methods

In this study, we used transcription regulatory network and master regulator analyses on transcriptomic data of human hippocampus to identify transcription factors (TFs) that can poten

SUBMITTER: Vargas DM 

PROVIDER: S-EPMC6015462 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature