Systemic Inflammatory Responses in Ulcerative Colitis Patients and Clostridium difficile Infection.

ABSTRACT:

Background/aims

Finding differences in systemic inflammatory response in ulcerative colitis (UC), UC with Clostridium difficile infection (CDI), and CDI could lead to a better ability to differentiate between UC with symptomatic CDI and UC with C. difficile colonization, and could identify specific inflammatory pathways for UC or CDI, which could be therapeutic targets.

Methods

We prospectively collected sera from symptomatic UC patients whose stools were tested for toxigenic C. difficile, and from CDI patients who did not have UC (CDI-noUC). The UC patients with positive tests (UC-CDI) were further categorized into responders to CDI treatment (UC-CDI-R) and non-responders (UC-CDI-NR). We compared serum inflammatory mediators among groups using unadjusted and adjusted multiv

SUBMITTER: Limsrivilai J 

PROVIDER: S-EPMC6015554 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature