Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation.

ABSTRACT: Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic automotive brake pads used in mid-size passenger cars by a full-scale brake dynamometer with an environmental chamber simulating urban driving and to deduce their potential hazard in vitro. The collected fractions were analysed using scanning electron microscopy via energy-dispersive X-ray spectroscopy (SEM-EDS) and Raman microspectroscopy. The biological impact of the samples was investigated using

SUBMITTER: Barosova H 

PROVIDER: S-EPMC6015608 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature