Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome.

ABSTRACT:

Background

Acute liver injury in patients with ARDS decreases survival but early stages may be easily missed due to the lack of sufficient biomarkers signalling its onset. Accordingly, we tested in ARDS patients the hypotheses that microRNA-122, the foremost liver-related microRNA (miR), 1) is an sensitive and specific early predictor for potential liver injury and 2) analysed its impact on 30-day-survival.

Methods

We collected clinical data and analysed blood samples from 119 ARDS patients within the first 24 h of ICU admission and from 20 patients undergoing elective abdominal non-liver surgery serving as controls. Total circulating miR was isolated from serum and relative miR-122 expression was measured (using specific probes and spiked-in miR-54), as were liver function

SUBMITTER: Rahmel T 

PROVIDER: S-EPMC6015662 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature