Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT Study.

ABSTRACT: Marinobufagenin (MBG) is an endogenous steroidal α1-Na⁺K⁺-ATPase inhibitor. Because of its role in sodium handling, MBG has been associated with both antihypertensive and prohypertensive effects in normal physiology and pathology. MBG is positively associated with blood pressure in Dahl salt-sensitive rats exhibiting a similar hypertensive phenotype to black populations, characterized by impaired urinary Na⁺ excretion. However, clinical studies exploring blood pressure (BP)-related effects of MBG in black populations are scant. We determined whether the MBG/Na⁺ ratio (assessing the effectiveness of Na⁺ excretion resistance to MBG) is related to systolic BP (SBP) in young black men and women, compared to whites. We included 331 apparent

SUBMITTER: Strauss M 

PROVIDER: S-EPMC6015745 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature