aaquetzalli is required for epithelial cell polarity and neural tissue formation in Drosophila.

ABSTRACT: Morphogenetic movements during embryogenesis require dynamic changes in epithelial cell polarity and cytoskeletal reorganization. Such changes involve, among others, rearrangements of cell-cell contacts and protein traffic. In Drosophila melanogaster, neuroblast delamination during early neurogenesis is a well-characterized process requiring a polarized neuroepithelium, regulated by the Notch signaling pathway. Maintenance of epithelial cell polarity ensues proper Notch pathway activation during neurogenesis. We characterize here aaquetzalli (aqz), a gene whose mutations affect cell polarity and nervous system specification. The aqz locus encodes a protein that harbors a domain with significant homology to a proline-rich conserved domain of nuclear receptor co-a

SUBMITTER: Mendoza-Ortiz MA 

PROVIDER: S-EPMC6015755 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature