Genetic Targeting of Organ-Specific Blood Vessels.

ABSTRACT:

Rationale

Organs of the body require vascular networks to supply oxygen and nutrients and maintain physiological function. The blood vessels of different organs are structurally and functionally heterogeneous in nature. To more precisely dissect their distinct in vivo function in individual organs, without potential interference from off-site targets, it is necessary to genetically target them in an organ-specific manner.

Objective

The objective of this study was to generate a genetic system that targets vascular endothelial cells in an organ- or tissue-specific manner and to exemplify the potential application of intersectional genetics for precise, target-specific gene manipulation in vivo.

Methods and results

We took advantage of 2 orthogonal recombination systems,

SUBMITTER: Pu W 

PROVIDER: S-EPMC6015762 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature