Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

ABSTRACT:

Purpose

To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Design

Multicenter, prospective cohort study.

Participants

A total of 1061 subjects in CATT.

Methods

Color photographic and fluorescein angiographic images from baseline and 1, 2, and 5 years were evaluated. Incidence of scar formation was estimated with Kaplan-Meier curves. Risk factors were assessed with Cox regression models.

Main outcome measures

Scar formation, fibrotic scar area, and macular atrophy associated with fibrotic scar ("atrophy").

Results

Cumulative proportion of eyes with scar was 32%, 46%, and 56% at years 1, 2, and 5, respectively. Baseline factors assoc

SUBMITTER: Daniel E 

PROVIDER: S-EPMC6015772 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature