Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of NOX2.

ABSTRACT: In patients with acute myeloid leukemia (AML), treatment with histamine dihydrochloride (HDC) and low-dose IL-2 (HDC/IL-2) in the post-chemotherapy phase has been shown to reduce the incidence of leukemic relapse. The clinical benefit of HDC/IL-2 is pronounced in monocytic forms of AML, where the leukemic cells express histamine type 2 receptors (H₂R) and the NAPDH oxidase-2 (NOX2). HDC ligates to H₂Rs to inhibit NOX2-derived formation of reactive oxygen species, but details regarding the anti-leukemic actions of HDC remain to be elucidated. Here, we report that human NOX2⁺ myelomonocytic/monocytic AML cell lines showed increased expression of maturation markers along with reduced leukemic cell proliferation after exposure to HDC in vitro. These effe

SUBMITTER: Kiffin R 

PROVIDER: S-EPMC6015904 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature