Dataset Information

Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics.

ABSTRACT:

Background

Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement.

Methods

Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations.

Results

In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012-2017, we noted tics in 11 patients (79%), which stand in stark contrast to the estimated lifetime prevalence of tics estimated to reach 1%.

Conclusions

The two reasons to point out this possible association are the clinical implications and the potential opportunity of a better understanding of shared pathophysiological mechanisms of neuronal hyperexcitability.

SUBMITTER: Balint B

PROVIDER: S-EPMC6016019 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics.

Balint Bettina B Wiethoff Sarah S Martino Davide D Del Gamba Claudia C Latorre Anna A Ganos Christos C Houlden Henry H Bhatia Kailash P KP

Movement disorders clinical practice 20180417 3

<h4>Background</h4>Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement.<h4>Methods</h4>Observational study with a cohort of 14 PKD patients and genetic testing for <i>PRRT2</i> mutations.<h4>Results</h4>In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012-2017, we noted tics in 11 patients (79%), which stand in stark contrast to the ...[more]

PMID: 29984260

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Project description:BackgroundParoxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder characterized by recurrent dystonic or choreoathetoid attacks triggered by sudden voluntary movements. Under the condition of psychological burden, some patients' attacks may get worsened with longer duration and higher frequency. This study aimed to assess nonmotor symptoms and quality of life of patients with PKD in a large population.MethodsWe performed a cross-sectional survey in 165 primary PKD patients from August 2008 to October 2016 in Rui Jin Hospital, using Symptom Check List-90-Revised (SCL-90-R), World Health Organization Quality of Life-100 (WHOQoL-100), Self-Rating Depression Scale, and Self-Rating Anxiety Scale. We evaluated the differences of SCL-90-R and WHOQOL-100 scores in patients and Chinese normative data (taken from literature) by using the unpaired Student's t-test. We applied multivariate linear regression to analyze the relationships between motor manifestations, mental health, and quality of life among PKD patients.ResultsCompared with Chinese normative data taken from literature, patients with PKD exhibited significantly higher (worse) scores across all SCL-90-R subscales (somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism; P= 0.000 for all) and significantly lower (worse) scores of five domains in WHOQoL-100 (physical domain, psychological domain, independence domain, social relationship domain, and general quality of life; P= 0.000 for all). Nonremission of dyskinesia episodes (P = 0.011) and higher depression score (P = 0.000) were significantly associated with lower levels of quality of life. The rates of depression and anxiety in patients with PKD were 41.2% (68/165) and 26.7% (44/165), respectively.ConclusionsDepression, anxiety, and low levels of quality of life were prevalent in patients with PKD. Co-occurrence of depression and anxiety was common among these patients. Regular mental health interventions could set depression and anxiety as intervention targets. Considering that the motor episodes could be elicited by voluntary movements and sometimes also by emotional stress, and that symptoms may get worsened with longer duration and higher frequency when patients are stressed out, intervention or treatment of depression and anxiety might improve the motor symptoms and overall quality of life in PKD patients.

Dataset Information

Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics.

Background

Methods

Results

Conclusions

Publications

Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics.

Similar Datasets

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