Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics.

ABSTRACT:

Background

Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement.

Methods

Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations.

Results

In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012-2017, we noted tics in 11 patients (79%), which stand in stark contrast to the estimated lifetime prevalence of tics estimated to reach 1%.

Conclusions

The two reasons to point out this possible association are the clinical implications and the potential opportunity of a better understanding of shared pathophysiological mechanisms of neuronal hyperexcitability.

SUBMITTER: Balint B 

PROVIDER: S-EPMC6016019 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature