Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study.

ABSTRACT: OBJECTIVE:To investigate whether exposure to metformin during the first trimester of pregnancy, for diabetes or other indications, increases the risk of all or specific congenital anomalies. DESIGN:Population based exploratory case-control study using malformed controls. Cases of 29 specific subgroups of non-genetic anomalies, and all non-genetic anomalies combined, were compared with controls (all other non-genetic anomalies or genetic syndromes). SETTING:11 EUROmediCAT European congenital anomaly registries surveying 1 892 482 births in Europe between 2006 and 2013. PARTICIPANTS:50 167 babies affected by congenital anomaly (41 242 non-genetic and 8925 genetic) including live births, fetal deaths from 20 weeks' gestation, and terminations of pregnancy for fetal anomaly. MAIN OUTCOME MEASU

SUBMITTER: Given JE 

PROVIDER: S-EPMC6016021 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature