Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is an esophageal inflammatory disease associated with atopic diseases. Thymic stromal lymphopoietin (TSLP) and calpain 14 (CAPN14) genetic variations contribute to EoE, but how this relates to atopy is unclear.

Objective

The purpose of this study was to explore the relationship between EoE, atopy, and genetic risk.

Methods

EoE-atopy enrichment was tested by using 700 patients with EoE and 801 community control subjects. Probing 372 single nucleotide polymorphisms (SNPs) in 63 atopy genes, we evaluated EoE associations using 412 nonatopic and 868 atopic disease control subjects. Interaction and stratified analyses of EoE-specific and atopy-related SNPs were performed.

Results

Atopic disease was enriched in patients with

SUBMITTER: Martin LJ 

PROVIDER: S-EPMC6016040 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature