The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.

ABSTRACT:

Aims

We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes.

Methods

PubMed and Cochrane database were searched up to July 1st 2016 for randomized controlled trials that assessed the relationship between vitamin D supplementation and glucose metabolism (change in hemoglobin A1C (HbA1C) and fasting blood glucose (FBG)) among adults with type 2 diabetes.

Results

Twenty nine trials (3324 participants) were included in the systematic review. Among 22 studies included in the meta-analysis, 19 reported HbA1C, 16 reported FBG outcomes and 15 were deemed poor quality. There was a modest reduction in HbA1C (-0.32% [-0.53 to -0.10], I²=91.9%) compared to placebo after vitamin D supplementation but no effect on

SUBMITTER: Lee CJ 

PROVIDER: S-EPMC6016376 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature