A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques.

ABSTRACT: The formation of beta amyloid (Aβ) plaques in specific brain regions is one of the early pathological hallmarks of Alzheimer's disease (AD). To enable the early detection of AD and related applications, a method for real-time, clear 3D visualization of Aβ plaques in vivo is highly desirable. Two-photon microscopy (TPM) which utilizes two near-infrared photons is an attractive tool for such applications. However, this technique needs a sensitive and photostable two-photon (TP) probe possessing bright TP exited fluorescence to impart high signal-to-noise (S/N) visualization of Aβ plaques. Herein, we report a quadrupolar TP fluorescent probe (QAD1) having large TP action cross section (Φδ_max = 420 GM) and its application for in vivo TPM imaging of Aβ pla

SUBMITTER: Heo CH 

PROVIDER: S-EPMC6016450 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature