New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human placenta.

ABSTRACT: Expression of placental growth factor (PGF) is closely associated with placental perfusion in early pregnancy. PGF is primarily expressed in placental trophoblasts, and its expression decreases in preeclampsia, associated with placental hypoxia. The transcription factors glial cells missing 1 (GCM1) and metal-regulatory transcription factor 1 (MTF1) have been implicated in the regulation of PGF gene expression through regulatory elements upstream and downstream of the PGF transcription start site, respectively. Here, we clarified the mechanism underlying placenta-specific PGF expression. We demonstrate that GCM1 up-regulates PGF expression through three downstream GCM1-binding sites (GBSs) but not a previously reported upstream GBS. Interestingly, we also found

SUBMITTER: Chiu YH 

PROVIDER: S-EPMC6016460 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature