Parental age and risk of genetic syndromes predisposing to nervous system tumors: nested case-control study.

ABSTRACT:

Purpose

Phacomatoses are genetic syndromes that are associated with increased risk of developing nervous system tumors. Phacomatoses are usually inherited, but many develop de novo, with unknown etiology. In this population-based study, we investigated the effect of parental age on the risk of phacomatoses in offspring.

Patients and methods

The study was a population-based nested case-control study. All individuals born and residing in Sweden between January 1960 and December 2010 were eligible for inclusion. Using the Patient Register, 4625 phacomatosis cases were identified and further classified as familial or nonfamilial. Ten matched controls per case were randomly selected from the eligible population. Data were analyzed using conditional logistic regression. Analyses w

SUBMITTER: Adel Fahmideh M 

PROVIDER: S-EPMC6016487 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature