Targeting the dopamine D₁ receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.

ABSTRACT:

Background and purpose

Insufficient prefrontal dopamine 1 (D₁ ) receptor signalling has been linked to cognitive dysfunction in several psychiatric conditions. Because the PDE1 isoform B (PDE1B) is postulated to regulate D₁ receptor-dependent signal transduction, in this study we aimed to elucidate the role of PDE1 in cognitive processes reliant on D₁ receptor function.

Experimental approach

Cognitive performance of the D₁ receptor agonist, SKF38393, was studied in the T-maze continuous alternation task and 5-choice serial reaction time task. D₁ receptor/PDE1B double-immunohistochemistry was performed using human and rat prefrontal brain sections. The pharmacological activity of the PDE1 inhibitor, ITI-214, was assessed

SUBMITTER: Pekcec A 

PROVIDER: S-EPMC6016630 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature