Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice.

ABSTRACT:

Background and purpose

The κ receptor antagonists have potential for treating neuropsychiatric disorders. We have investigated the in vivo pharmacology of a novel buprenorphine analogue, BU10119, for the first time.

Experimental approach

To determine the opioid pharmacology of BU10119 (0.3-3 mg·kg^-1 , i.p.) in vivo, the warm-water tail-withdrawal assay was applied in adult male CD1 mice. A range of behavioural paradigms was used to investigate the locomotor effects, rewarding properties and antidepressant or anxiolytic potential of BU10119. Additional groups of mice were exposed to a single (1 × 2 h) or repeated restraint stress (3× daily 2 h) to determine the ability of BU10119 to block stress-induced analgesia.

Key results

BU10119 alone was without any an

SUBMITTER: Almatroudi A 

PROVIDER: S-EPMC6016679 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature