PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers.

ABSTRACT:

Aims

Prior studies have established variation at the PNPLA3 gene to be associated with a risk of developing alcoholic liver disease (ALD). We attempt to replicate this finding and other potential genetic variations previously associated with ALD utilizing a case-control design in a cohort of subjects with alcohol use disorders.

Short summary

This case-control study performed in a US clinical sample of heavy drinkers, replicates the previously reported association between ALD and rs738409 polymorphism in the PNPLA3 gene in heavy drinkers. This association persisted after accounting for the subject's diabetes status.

Methods

Patients of European ancestry with a history of ALD were identified (n = 169). Controls consisted of patients without ALD who were from the same co

SUBMITTER: Kolla BP 

PROVIDER: S-EPMC6016697 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature