Individuality and slow dynamics in bacterial growth homeostasis.

ABSTRACT: Microbial growth and division are fundamental processes relevant to many areas of life science. Of particular interest are homeostasis mechanisms, which buffer growth and division from accumulating fluctuations over multiple cycles. These mechanisms operate within single cells, possibly extending over several division cycles. However, all experimental studies to date have relied on measurements pooled from many distinct cells. Here, we disentangle long-term measured traces of individual cells from one another, revealing subtle differences between temporal and pooled statistics. By analyzing correlations along up to hundreds of generations, we find that the parameter describing effective cell size homeostasis strength varies significantly among cells. At the same time, we find an invariant

SUBMITTER: Susman L 

PROVIDER: S-EPMC6016764 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature