Distinguishing malignant from benign microscopic skin lesions using desorption electrospray ionization mass spectrometry imaging.

ABSTRACT: Detection of microscopic skin lesions presents a considerable challenge in diagnosing early-stage malignancies as well as in residual tumor interrogation after surgical intervention. In this study, we established the capability of desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to distinguish between micrometer-sized tumor aggregates of basal cell carcinoma (BCC), a common skin cancer, and normal human skin. We analyzed 86 human specimens collected during Mohs micrographic surgery for BCC to cross-examine spatial distributions of numerous lipids and metabolites in BCC aggregates versus adjacent skin. Statistical analysis using the least absolute shrinkage and selection operation (Lasso) was employed to categorize each 200-µm-diameter picture element (pixel) of inves

SUBMITTER: Margulis K 

PROVIDER: S-EPMC6016785 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature