Memory-related hippocampal activation in the sleeping toddler.

ABSTRACT: Nonhuman research has implicated developmental processes within the hippocampus in the emergence and early development of episodic memory, but methodological challenges have hindered assessments of this possibility in humans. Here, we delivered a previously learned song and a novel song to 2-year-old toddlers during natural nocturnal sleep and, using functional magnetic resonance imaging, found that hippocampal activation was stronger for the learned song compared with the novel song. This was true regardless of whether the song was presented intact or backwards. Toddlers who remembered where and in the presence of which toy character they heard the song exhibited stronger hippocampal activation for the song. The results establish that hippocampal activation in toddlers reflects past exper

SUBMITTER: Prabhakar J 

PROVIDER: S-EPMC6016818 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature