Nonprimary Maternal Cytomegalovirus Infection After Viral Shedding in Infants.

ABSTRACT:

Background

Most infants with congenital Cytomegalovirus (CMV) infection are born to seropositive women as a result of maternal CMV nonprimary infection (reinfection or reactivation). Although infected children are known to transmit CMV to their seronegative mothers, the frequency and magnitude of nonprimary maternal CMV infection after exposure to viral shedding by children in their household have not been characterized.

Methods

A cohort of Ugandan newborns and their mothers were tested weekly for CMV by quantitative polymerase chain reaction of oral swabs. Infant primary infection and maternal nonprimary infection were defined by the onset of persistent high-level oral CMV shedding. Strain-specific antibody testing was used to assess maternal reinfection. Cox regression mod

SUBMITTER: Boucoiran I 

PROVIDER: S-EPMC6016842 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature