Genome-wide meta-analysis identifies novel loci associated with parathyroid hormone level.

ABSTRACT:

Background

Parathyroid hormone (PTH) is one of the principal regulators of calcium homeostasis. Although serum PTH level is mostly accounted by genetic factors, genetic background underlying PTH level is insufficiently known. Therefore, the aim of this study was to identify novel genetic variants associated with PTH levels.

Methods

We performed GWAS meta-analysis within two genetically isolated Croatian populations followed by replication analysis in a Croatian mainland population and we also combined results across all three analyzed populations. The analyses included 2596 individuals. A total of 7,411,206 variants, imputed using the 1000 Genomes reference panel, were analysed for the association. In addition, a sex-specific GWAS meta-analyses were performed.

Results

SUBMITTER: Matana A 

PROVIDER: S-EPMC6016867 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature