Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction.

ABSTRACT: BACKGROUND:Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve. However, despite the high prevalence of HF with preserved ejection fraction (HFpEF) in our society, it is not clear what changes in cardiac energy metabolism occur in HFpEF, and whether alterations in energy metabolism contribute to the development of contractile dysfunction. METHODS:We directly assessed overall energy metabolism during the development of HFpEF in Dahl salt-sensitive rats fed a high salt diet (HSD) for 3, 6 and 9 weeks. RESULTS:Over the course of 9 weeks, the HSD caused a progressive decrease in diastolic function (assessed by echocardi

SUBMITTER: Fillmore N 

PROVIDER: S-EPMC6016884 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature