Neuroimmune semaphorins as costimulatory molecules and beyond.
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ABSTRACT:
SUBMITTER: Chapoval SP
PROVIDER: S-EPMC6016892 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Neuroimmune semaphorins as costimulatory molecules and beyond.
Molecular medicine (Cambridge, Mass.) 20180404 1
Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as "neuroimmune semaphorins". They have been shown to regulate T cell activation by serving as costimulatory molecules. Similar to classical costimulatory molecules, neuroimmune semaphorins are either constitutively or inducibly expressed on immune cells. In contrast to the classical costimulatory molecule function, the action of neuroimmune ...[more]
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