Whole blood transcriptome analysis in amyotrophic lateral sclerosis: A biomarker study.

ABSTRACT: The biological pathways involved in amyotrophic lateral sclerosis (ALS) remain elusive and diagnostic decision-making can be challenging. Gene expression studies are valuable in overcoming such challenges since they can shed light on differentially regulated pathways and may ultimately identify valuable biomarkers. This two-stage transcriptome-wide study, including 397 ALS patients and 645 control subjects, identified 2,943 differentially expressed transcripts predominantly involved in RNA binding and intracellular transport. When batch effects between the two stages were overcome, three different models (support vector machines, nearest shrunken centroids, and LASSO) discriminated ALS patients from control subjects in the validation stage with high accuracy. The models' accuracy reduced c

SUBMITTER: van Rheenen W 

PROVIDER: S-EPMC6016933 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature