An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone.

ABSTRACT: Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.

SUBMITTER: Tyrikos-Ergas T 

PROVIDER: S-EPMC6017073 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature