Microbial Oxidation of the Fusidic Acid Side Chain by Cunninghamella echinulata.

ABSTRACT: Biotransformation of fusidic acid (1) was accomplished using a battery of microorganisms including Cunninghamella echinulata NRRL 1382, which converted fusidic acid (1) into three new metabolites 2⁻4 and the known metabolite 5. These metabolites were identified using 1D and 2D NMR and HRESI-FTMS data. Structural assignment of the compounds was supported via computation of ¹H- and ¹³C-NMR chemical shifts. Compounds 2 and 3 were assigned as the 27-hydroxy and 26-hydroxy derivatives of fusidic acid, respectively. Subsequent oxidation of 3 afforded aldehyde 4 and the dicarboxylic acid 5. Compounds 2, 4 and 5 were screened for antimicrobial activity against different Gram positive and ne

SUBMITTER: Ibrahim AS 

PROVIDER: S-EPMC6017311 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature