Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells.

ABSTRACT: Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE₂ in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A₂, which has been previously shown to reduce PGE₂ synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE₂ production, similar to that observed for GK115.

SUBMITTER: Vasilakaki S 

PROVIDER: S-EPMC6017359 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature