Synthesis of Novel Amino Acid-Fipronil Conjugates and Study on Their Phloem Loading Mechanism.

ABSTRACT: To develop a new pesticide with phloem mobility, a series of new amino acid-fipronil conjugates were designed and synthesized based on derivatization at the 3-position of the pyrazole ring of fipronil. Experiments using a Ricinus communis seedling system showed that all tested conjugates were phloem mobile except for the isoleucine-fipronil conjugate, and that the serine-fipronil conjugate (4g) exhibited the highest concentration in phloem sap (52.00 ± 5.80 μM). According to prediction with log Cf values and uptake experiments with Xenopus oocytes, the phloem loading process of conjugate 4g involved both passive diffusion and an active carrier system (RcANT15). In particular, compared with for a previously reported glycinergic-fipronil conjugate (GlyF), passive diffusion played a more impo

SUBMITTER: Sheng Q 

PROVIDER: S-EPMC6017586 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature