HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data.

ABSTRACT: Research and development of new antiretroviral agents are in great demand due to issues with safety and efficacy of the antiretroviral drugs. HIV reverse transcriptase (RT) is an important target for HIV treatment. RT inhibitors targeting early stages of the virus-host interaction are of great interest for researchers. There are a lot of clinical and biochemical data on relationships between the occurring of the single point mutations and their combinations in the pol gene of HIV and resistance of the particular variants of HIV to nucleoside and non-nucleoside reverse transcriptase inhibitors. The experimental data stored in the databases of HIV sequences can be used for development of methods that are able to predict HIV resistance based on amino acid or nucleotide sequences. The data on

SUBMITTER: Tarasova O 

PROVIDER: S-EPMC6017644 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature