Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes.

ABSTRACT: Due to synergistic effects, combinatorial drugs are widely used for treating complex diseases. However, combining drugs and making them synergetic remains a challenge. Genetic disease genes are considered a promising source of drug targets with important implications for navigating the drug space. Most diseases are not caused by a single pathogenic factor, but by multiple disease genes, in particular, interacting disease genes. Thus, it is reasonable to consider that targeting epistatic disease genes may enhance the therapeutic effects of combinatorial drugs. In this study, synthetic lethality gene pairs of tumors, similar to epistatic disease genes, were first targeted by combinatorial drugs, resulting in the enrichment of the combinatorial drugs with cancer treatment, which verified our

SUBMITTER: Quan Y 

PROVIDER: S-EPMC6017788 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature