Ontology highlight
ABSTRACT:
SUBMITTER: Quan Y
PROVIDER: S-EPMC6017788 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Quan Yuan Y Liu Meng-Yuan MY Liu Ye-Mao YM Zhu Li-Da LD Wu Yu-Shan YS Luo Zhi-Hui ZH Zhang Xiu-Zhen XZ Xu Shi-Zhong SZ Yang Qing-Yong QY Zhang Hong-Yu HY
Molecules (Basel, Switzerland) 20180323 4
Due to synergistic effects, combinatorial drugs are widely used for treating complex diseases. However, combining drugs and making them synergetic remains a challenge. Genetic disease genes are considered a promising source of drug targets with important implications for navigating the drug space. Most diseases are not caused by a single pathogenic factor, but by multiple disease genes, in particular, interacting disease genes. Thus, it is reasonable to consider that targeting epistatic disease ...[more]