Synthesis and Anticandidal Activity of New Imidazole-Chalcones.

ABSTRACT: In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl)prop-2-en-1-one derivatives (3a−3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole derivatives (3a−3o) were characterized by IR, ¹H-NMR, ¹³C-NMR, and LCMSMS spectroscopic methods. The anticandidal activity of compounds (3a−3o) against C. albicans (ATCC 24433), C. krusei (ATCC 6258), C. parapsilosis (ATCC 22019), and C. glabrata (ATCC 90030) was elucidated according to the EUCAST definitive (EDef 7.1) method. Consistent with the activity studies, 3a−3d were found to be more potent derivatives with their MIC₅₀ values (0.78 µg/mL−3.125 µg/mL) against <

SUBMITTER: Osmaniye D 

PROVIDER: S-EPMC6017838 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature