Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys.

ABSTRACT: Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult monkeys prevents allocentric spatial relational learning, whereas spatial learning persists following neonatal lesion. Here, we quantified the number of cells expressing the immediate-early gene c-fos, a marker of neuronal activity, to characterize the functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion. Ninety minutes before brain collection, three control and four adult monkeys with bilateral neonatal hippocampal lesions explored a novel enviro

SUBMITTER: Chareyron LJ 

PROVIDER: S-EPMC6018021 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature