Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression.

ABSTRACT:

Objective

Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD.

Methods

A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in ca

SUBMITTER: Sohn H 

PROVIDER: S-EPMC6018146 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature