A Bead-Based Flow Cytometric Assay for Monitoring Yersinia pestis Exposure in Wildlife.

ABSTRACT: Yersinia pestis is the causative agent of plague and is considered a category A priority pathogen due to its potential for high transmissibility and the significant morbidity and mortality it causes in humans. Y. pestis is endemic to the western United States and much of the world, necessitating programs to monitor for this pathogen on the landscape. Elevated human risk of plague infection has been spatially correlated with spikes in seropositive wildlife numbers, particularly rodent-eating carnivores, which are frequently in contact with the enzootic hosts and the associated arthropod vectors of Y. pestis In this study, we describe a semiautomated bead-based flow cytometric assay developed for plague monitoring in wildlife called the F1 Luminex plague assay (F1-LPA).

SUBMITTER: Chandler JC 

PROVIDER: S-EPMC6018325 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature