In vitro upconverting/downshifting luminescent detection of tumor markers based on Eu³⁺-activated core-shell-shell lanthanide nanoprobes.

ABSTRACT: Trivalent europium (Eu³⁺) doped inorganic nanoparticles (NPs), emerging as a new class of red luminescent nanoprobes, have shown great promise in bioapplications as diverse as luminescent bioassays and disease theranostics owing to their superior optical properties such as long-lived downshifting luminescence (DSL) and upconverting luminescence (UCL). However, the exploration of Eu³⁺-doped NPs as red luminescent bioprobes particularly combined with DSL and UCL of Eu³⁺ hitherto remains untouched. Herein, we report a rational core-shell-shell (CSS) design strategy to construct Eu³⁺-activated NaGdF₄:Yb/Tm@NaGdF₄:Eu@NaEuF₄ CSS NPs functionalized with efficient UCL and dissolution-enhanced DSL of Eu³⁺ for

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6018526 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature