Visible light amination/Smiles cascade: access to phthalazine derivatives.

ABSTRACT: We report the synthesis of various phthalazines via a new cascade reaction, initiated by visible light photocatalysis, involving a radical hydroamination reaction followed by a radical Smiles rearrangement. Phthalazine derivatives are obtained in high yields and from a broad scope readily accessible ortho-alkynylsulfonohydrazone precursors. The mild photoredox conditions ensure an excellent functional group tolerance. Application of this strategy to a one-pot protocol starting from the corresponding carbonyl compounds, and subsequent functionalization allow the rapid synthesis of structurally diverse structures.

SUBMITTER: Brachet E 

PROVIDER: S-EPMC6018559 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature