How distributed processing produces false negatives in voxel-based lesion-deficit analyses.

ABSTRACT: In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits arising at the word retrieval level. A highly significant lesion-deficit relationship was identified in left temporal and frontal/premotor regions. Post-hoc analyses showed

SUBMITTER: Gajardo-Vidal A 

PROVIDER: S-EPMC6018567 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature