An important step towards a prevascularized islet macroencapsulation device-effect of micropatterned membranes on development of endothelial cell network.

ABSTRACT: The development of immune protective islet encapsulation devices could allow for islet transplantation in the absence of immunosuppression. However, the immune protective membrane / barrier introduced there could also impose limitations in transport of oxygen and nutrients to the encapsulated cells resulting to limited islet viability. In the last years, it is well understood that achieving prevascularization of the device in vitro could facilitate its connection to the host vasculature after implantation, and therefore could provide sufficient blood supply and oxygenation to the encapsulated islets. However, the microvascular networks created in vitro need to mimic well the highly organized vasculature of the native tissue. In earlier study, we developed a functional macroencapsulation de

SUBMITTER: Skrzypek K 

PROVIDER: S-EPMC6018599 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature